The Royals have released game times for the 2016 season, beginning with their Opening Day contest on ESPN Sunday Night Baseball on April 3 against the team the Royals defeated in last year's World Series, the New York Mets. The Royals will have three off days in the first week before heading on the road in an ALDS re-match against the Houston Astros on April 11.
The Royals will experiment with a different start time, beginning many games at 15 minutes past the hour, rather than five minutes past the hour as they did last year. They will also try some earlier weekday night games while school is still in session, with games starting at 6:15 for their April series against the Tigers, a 6:05 start on May 16 against the Red Sox and several 6:15 starts in September against the Athletics, White Sox, and Twins.
| Date | Opponent | Time |
| Sun, 4/3 | Mets | 7:37p |
| Tue, 4/5 | Mets | 3:15p |
| Fri, 4/8 | Twins | 7:15p |
| Sat, 4/9 | Twins | 6:15p |
| Sun, 4/10 | Twins | 1:15p |
| Mon, 4/11 | at Astros | 7:10p |
| Tue, 4/12 | at Astros | 7:10p |
| Wed, 4/13 | at Astros | 7:10p |
| Thu, 4/14 | at Astros | 7:10p |
| Fri, 4/15 | at Athletics | 9:05p |
| Sat, 4/16 | at Athletics | 3:05p |
| Sun, 4/17 | at Athletics | 3:05p |
| Tue, 4/19 | Tigers | 6:15p |
| Wed, 4/20 | Tigers | 6:15p |
| Thu, 4/21 | Tigers | 6:15p |
| Fri, 4/22 | Orioles | 7:15p |
| Sat, 4/23 | Orioles | 6:15p |
| Sun, 4/24 | Orioles | 1:15p |
| Mon, 4/25 | at Angels | 9:05p |
| Tue, 4/26 | at Angels | 9:05p |
| Wed, 4/27 | at Angels | 9:05p |
| Fri, 4/29 | at Mariners | 9:10p |
| Sat, 4/30 | at Mariners | 8:10p |
| Sun, 5/1 | at Mariners | 3:10p |
| Mon, 5/2 | Nationals | 7:15p |
| Tue, 5/3 | Nationals | 7:15p |
| Wed, 5/4 | Nationals | 1:15p |
| Fri, 5/6 | at Indians | 6:10p |
| Sat, 5/7 | at Indians | 3:10p |
| Sun, 5/8 | at Indians | 12:10p |
| Mon, 5/9 | at Yankees | 6:05p |
| Tue, 5/10 | at Yankees | 6:05p |
| Wed, 5/11 | at Yankees | 6:05p |
| Thu, 5/12 | at Yankees | 6:05p |
| Fri, 5/13 | Braves | 7:15p |
| Sat, 5/14 | Braves | 6:15p |
| Sun, 5/15 | Braves | 1:15p |
| Mon, 5/16 | Red Sox | 6:05p |
| Tue, 5/17 | Red Sox | 7:15p |
| Wed, 5/18 | Red Sox | 1:15p |
| Fri, 5/20 | at White Sox | 7:10p |
| Sat, 5/21 | at White Sox | 1:10p |
| Sun, 5/22 | at White Sox | 1:10p |
| Mon, 5/23 | at Twins | 7:10p |
| Tue, 5/24 | at Twins | 7:10p |
| Wed, 5/25 | at Twins | 12:10p |
| Thu, 5/26 | White Sox | 7:15p |
| Fri, 5/27 | White Sox | 7:15p |
| Sat, 5/28 | White Sox | 1:15p |
| Sun, 5/29 | White Sox | 1:15p |
| Mon, 5/30 | Rays | 7:15p |
| Tue, 5/31 | Rays | 7:15p |
| Wed, 6/1 | Rays | 7:15p |
| Thu, 6/2 | at Indians | 6:10p |
| Fri, 6/3 | at Indians | 6:10p |
| Sat, 6/4 | at Indians | 6:15p |
| Sun, 6/5 | at Indians | 12:10p |
| Mon, 6/6 | at Orioles | 6:05p |
| Tue, 6/7 | at Orioles | 6:05p |
| Wed, 6/8 | at Orioles | 6:05p |
| Fri, 6/10 | at White Sox | 7:10p |
| Sat, 6/11 | at White Sox | 1:10p |
| Sun, 6/12 | at White Sox | 1:10p |
| Mon, 6/13 | Indians | 7:15p |
| Tue, 6/14 | Indians | 7:15p |
| Wed, 6/15 | Indians | 7:15p |
| Thu, 6/16 | Tigers | 7:15p |
| Fri, 6/17 | Tigers | 7:15p |
| Sat, 6/18 | Tigers | 7:15p |
| Sun, 6/19 | Tigers | 1:15p |
| Tue, 6/21 | at Mets | 6:10p |
| Wed, 6/22 | at Mets | 12:10p |
| Fri, 6/24 | Astros | 7:15p |
| Sat, 6/25 | Astros | 6:15p |
| Sun, 6/26 | Astros | 1:15p |
| Mon, 6/27 | Cardinals | 7:15p |
| Tue, 6/28 | Cardinals | 7:15p |
| Wed, 6/29 | at Cardinals | 7:15p |
| Thu, 6/30 | at Cardinals | 6:15p |
| Fri, 7/1 | at Phillies | 6:05p |
| Sat, 7/2 | at Phillies | 4:50p |
| Sun, 7/3 | at Phillies | 12:35p |
| Mon, 7/4 | at Blue Jays | 6:07p |
| Tue, 7/5 | at Blue Jays | 6:07p |
| Wed, 7/6 | at Blue Jays | 6:07p |
| Thu, 7/7 | Mariners | 7:15p |
| Fri, 7/8 | Mariners | 7:15p |
| Sat, 7/9 | Mariners | 3:15p |
| Sun, 7/10 | Mariners | 1:15p |
| Fri, 7/15 | at Tigers | 6:08p |
| Sat, 7/16 | at Tigers | 6:08p |
| Sun, 7/17 | at Tigers | 12:08p |
| Mon, 7/18 | Indians | 7:15p |
| Tue, 7/19 | Indians | 7:15p |
| Wed, 7/20 | Indians | 1:15p |
| Fri, 7/22 | Rangers | 7:15p |
| Sat, 7/23 | Rangers | 6:15p |
| Sun, 7/24 | Rangers | 1:15p |
| Mon, 7/25 | Angels | 7:15p |
| Tue, 7/26 | Angels | 7:15p |
| Wed, 7/27 | Angels | 7:15p |
| Thu, 7/28 | at Rangers | 7:05p |
| Fri, 7/29 | at Rangers | 7:05p |
| Sat, 7/30 | at Rangers | 7:05p |
| Sun, 7/31 | at Rangers | 1:05p |
| Mon, 8/1 | at Rays | 6:10p |
| Tue, 8/2 | at Rays | 6:10p |
| Wed, 8/3 | at Rays | 6:10p |
| Thu, 8/4 | at Rays | 11:10a |
| Fri, 8/5 | Blue Jays | 7:15p |
| Sat, 8/6 | Blue Jays | 6:15p |
| Sun, 8/7 | Blue Jays | 1:15p |
| Tue, 8/9 | White Sox | 7:15p |
| Wed, 8/10 | White Sox | 7:15p |
| Thu, 8/11 | White Sox | 7:15p |
| Fri, 8/12 | at Twins | 7:10p |
| Sat, 8/13 | at Twins | 6:10p |
| Sun, 8/14 | at Twins | 1:10p |
| Mon, 8/15 | at Tigers | 6:08p |
| Tue, 8/16 | at Tigers | 6:08p |
| Wed, 8/17 | at Tigers | 6:08p |
| Thu, 8/18 | Twins | 7:15p |
| Fri, 8/19 | Twins | 7:15p |
| Sat, 8/20 | Twins | 6:15p |
| Sun, 8/21 | Twins | 1:15p |
| Tue, 8/23 | at Marlins | 6:10p |
| Wed, 8/24 | at Marlins | 6:10p |
| Thu, 8/25 | at Marlins | 6:10p |
| Fri, 8/26 | at Red Sox | 6:10p |
| Sat, 8/27 | at Red Sox | 6:10p |
| Sun, 8/28 | at Red Sox | 12:35p |
| Mon, 8/29 | Yankees | 7:15p |
| Tue, 8/30 | Yankees | 7:15p |
| Wed, 8/31 | Yankees | 7:15p |
| Fri, 9/2 | Tigers | 7:15p |
| Sat, 9/3 | Tigers | 6:15p |
| Sun, 9/4 | Tigers | 1:15p |
| Mon, 9/5 | at Twins | 1:10p |
| Tue, 9/6 | at Twins | 7:10p |
| Wed, 9/7 | at Twins | 7:10p |
| Fri, 9/9 | at White Sox | 7:10p |
| Sat, 9/10 | at White Sox | 6:10p |
| Sun, 9/11 | at White Sox | 1:10p |
| Mon, 9/12 | Athletics | 6:15p |
| Tue, 9/13 | Athletics | 6:15p |
| Wed, 9/14 | Athletics | 6:15p |
| Thu, 9/15 | Athletics | 6:15p |
| Fri, 9/16 | White Sox | 7:15p |
| Sat, 9/17 | White Sox | 6:15p |
| Sun, 9/18 | White Sox | 1:15p |
| Tue, 9/20 | at Indians | 6:10p |
| Wed, 9/21 | at Indians | 6:10p |
| Thu, 9/22 | at Indians | 6:10p |
| Fri, 9/23 | at Tigers | 6:08p |
| Sat, 9/24 | at Tigers | 6:08p |
| Sun, 9/25 | at Tigers | 12:08p |
| Tue, 9/27 | Twins | 6:15p |
| Wed, 9/28 | Twins | 6:15p |
| Thu, 9/29 | Twins | 6:15p |
| Fri, 9/30 | Indians | 7:15p |
| Sat, 10/1 | Indians | 6:15p |
| Sun, 10/2 | Indians | 2:15p |